Penn Quantitative Imaging Resource for Pancreatic Cancer


Publications

  1. Li Y, Joaquim MR, Pickup S, Song HK, Zhou R, Fan Y: Learning ADC maps from accelerated radial k-space diffusion-weighted MRI in mice using a deep CNN-transformer model. Magnetic Resonance in Medicine. 2024;91:105-17.
  2. Muller FM, Vervenne B, Maebe J, Blankemeyer E, Sellmyer MA, Zhou R, et al: Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability. Molecular Imaging Biology. 2024;26:101-13.
  3. Gammon ST, Cohen AS, Lehnert AL, Sullivan DC, Malyarenko D, Manning HC, et al: An Online Repository for Pre-Clinical Imaging Protocols (PIPs). Tomography: A journal for imaging research. 2023;9:750-8.
  4. Peehl DM, Badea CT, Chenevert TL, Daldrup-Link HE, Ding L, Dobrolecki LE, Houghton AM, Kinahan PE, Kurhanewicz J, Lewis MT, Li S, Luker GD, Ma CX, Manning HC, Mowery YM, O'Dwyer PJ, Pautler RG, Rosen MA, Roudi R, Ross BD, Shoghi KI, Sriram R, Talpaz M, Wahl RL and Zhou R: Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials. Tomography: A journal for imaging research. 2023;9:657-680.
  5. Moore SM, Quirk JD, Lassiter AW, Laforest R, Ayers GD, Badea CT, Fedorov AY, Kinahan PE, Holbrook M, Larson PEZ, Sriram R, Chenevert TL, Malyarenko D, Kurhanewicz J, Houghton AM, Ross BD, Pickup S, Gee JC, Zhou R, Gammon ST, Manning HC, Roudi R, Daldrup-Link HE, Lewis MT, Rubin DL, Yankeelov TE and Shoghi KI: Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging. Tomography : a journal for imaging research. 2023;9:995-1009.
  6. Malyarenko D, Amouzandeh G, Pickup S, Zhou R, Manning HC, Gammon ST, Shoghi KI, Quirk JD, Sriram R, Larson P, Lewis MT, Pautler RG, Kinahan PE, Muzi M and Chenevert TL: Evaluation of Apparent Diffusion Coefficient Repeatability and Reproducibility for Preclinical MRIs Using Standardized Procedures and a Diffusion-Weighted Imaging Phantom: Tomography : a journal for imaging research. 2023;9:375-386.
  7. Cao J, Pickup S, Rosen M and Zhou R.Impact of Arterial Input Function and Pharmacokinetic Models on DCE-MRI Biomarkers for Detection of Vascular Effect Induced by Stroma-Directed Drug in an Orthotopic Mouse Model of Pancreatic Cancer: Mol Imaging Biol. 2023.
  8. Kinahan PE, Kurhanewicz J, Lewis MT, Li S, Luker GD, Ma CX, Manning HC, Mowery YM, O'Dwyer PJ, Pautler RG, Rosen MA, Roudi R, Ross BD, Shoghi KI, Sriram R, Talpaz M, Wahl RL and Zhou R: Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials. Tomography : a journal for imaging research. 2023;9:657-680.
  9. S. Pickup, M. Romanello, M. Gupta, H.K. Song, R. Zhou. Dynamic Contrast-Enhanced MRI in the Abdomen of Mice with High Temporal and Spatial Resolution Using Stack-of-Stars Sampling and KWIC Reconstruction, Tomography : a journal for imaging research 8(5) (2022) 2113-2128.
  10. Cao J, Pickup S, Clendenin C, Blouw B, Choi H, Kang D, Rosen M, O'Dwyer PJ and Zhou R. Dynamic contrast-enhanced MRI detects responses to stroma-directed therapy in mouse models of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2019; 25:2314-2322.
  11. Shoghi K, Badea C, Blocker S, Chenevert T, Laforest R, Lewis M, Luker G, Manning H, Marcus D, Mowery Y, Pickup S, Richmond A, Ross B, Vilgelm A, Yankeelov T, Zhou R. Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. Tomography: A journal for imaging research. 2020; 6(3):273-287.
  12. Cao J, Song HK, Yang H, Castillo V, Chen J, Clendenin C, Rosen M, Zhou R, Pickup S. Respiratory Motion Mitigation and Repeatability of Two Diffusion-Weighted MRI Methods Applied to a Murine Model of Spontaneous Pancreatic Cancer. Tomography: A journal for imaging research. 2021; 7(1):66-79.
  13. Du T, Zhang H, Li Y, Pickup S, Rosen M, Zhou R, Song HK, Fan Y. Adaptive convolutional neural networks for accelerating magnetic resonance imaging via k-space data interpolation. Medical Image Analysis. 2021; 72.
  14. Romanello Joaquim M, Furth EE, Fan Y, Song HK, Pickup S, Cao J, Choi H, Gupta M, Cao Q, Shinohara R, McMenamin D, Clendenin C, Karasic TB, Duda J, Gee JC, O’Dwyer PJ, Rosen MA, Zhou R.DWI Metrics Differentiating Benign Intraductal Papillary Mucinous Neoplasms from Invasive Pancreatic Cancer: A Study in GEM Models. Cancers. 2022; 14(16):4017.

Proceedings

  1. Mamta Gupta, Hoon Choi, Thomas Karasic, Miguel Joaquim, Emma E Furth, Stephen Pickup, Cynthia Clendenin, Hee Kwon Song, Yong Fan, Jeffrey Duda, James Gee, Mark Rosen, Peter O'Dwyer, Rong Zhou: Quantitative MRI metrics and Transcriptome analysis reveal effects of stroma-directed drug and chemotherapy for in a GEM model of pancreatic cancer. Co-clinical Imaging Resource Program (CIRP) Network Annual Meeting May 2023.
  2. Yuemeng Li, Miguel Romanello Giroud Joaquim, Stephen Pickup, Hee Kwon Song, Rong Zhou, Yong Fan: Learning Apparent Diffusion Coefficient Maps from Accelerated Radial k-Space Diffusion-Weighted MRI in Mice using a Deep CNN-Transformer Model. Co-clinical Imaging Resource Program (CIRP) Network Annual Meeting May 2023.
  3. Mamta Gupta, Hoon Choi, Thomas Karasic, Miguel Joaquim, Emma E Furth, Stephen Pickup, Cynthia Clendenin, Hee Kwon Song, Yong Fan, Jeffrey Duda, James Gee, Mark Rosen, Peter O'Dwyer, Rong Zhou: Quantitative MRI metrics and Transcriptome analysis reveal effects of stroma-directed drug and chemotherapy for in a GEM model of pancreatic cancer. 2023 Pendergrass Symposium of Radiology Department (Earned magna cum laude designation) June 2023.
  4. Cao J, Choi H, Pantel P, Kranseler D, Mankoff DA and Zhou R: Dynamic PET Imaging Marker of Glutaminase Inhibition in Triple Negative Breast Cancer. Proceeding of Society of Nuclear Medicine and Molecular Imaging (SNMMI) June 2019.
  5. Hoon Choi, Austin Pantel, Prashanth Padakanti, Hanwen Yang, Jianbo Cao, Shihong Li, Yin-Ming Kuo, Hsiaoju Lee, David Mankoff and Rong Zhou: Towards Quantitative Modeling of Dynamic [11C]Glutamine PET for Probing Cancer Glutaminolysis World Molecular Imaging Congress (WMIC) 2019 annual meeting, Montreal, Canada Dec 2019.
  6. Jianbo Cao, MS, Stephen Pickup, PhD and Rong Zhou, PhD: Quantitative analyses of dynamic contrast enhanced MRI for detection of pancreatic cancer responses to stroma-directed drug: the role of arterial input function and pharmacokinetic model. World Molecular Imaging Congress (WMIC) 2019 annual meeting, Montreal, Canada Dec 2019.
  7. Rong Zhou: Penn Quantitative Imaging Resource for Pancreatic Cancer. World Molecular Imaging Congress (WMIC) 2019 annual meeting, Montreal, Canada Dec 2019 Notes: Presented at Spot Light Session-5 "Co-clinical Imaging in Precision Medicine"
  8. Jianbo Cao, Stephen Pickup, Hanwen Yang, Victor Castillo, Cynthia Clendenin, Peter O'Dwyer, Mark Rosen and Rong Zhou: Radial diffusion-weighted MRI enables motion-robustness and reproducibility for orthotopic pancreatic cancer in mouse. Proceedings of International Society of Magnetic Resonance in Medicine 2020.
  9. Jianbo Cao, Stephen Pickup, Hee Kwon Song and Rong Zhou: Radial sampling and KWIC-reconstruction reduce motion artifacts and improve spatial resolution for DCE-MRI of mouse pancreatic cancer. Proceedings of International Society of Magnetic Resonance in Medicine 2020.
  10. Jianbo Cao, Stephen Pickup, Hee Kwon Song, Cynthia Clendenin, Barbara Blouw, Hoon Choi, David Kang, Mark Rosen Peter O'Dwyer and Rong Zhou: Dynamic contrast enhanced-MRI is sensitive for detection of exocrine pancreas ductal adenocarcinoma to stroma directed-drug and motion-robust strategies. NIH/NIDDK Symposium on Imaging the Pancreas in Diabetes, Benign and Malignant Exocrine Pancreatic Disease 2020.
  11. Jianbo Cao, Stephen Pickup, Peter O'Dwyer, Mark Rosen and Rong Zhou: How the choice of PK model and AIF affect DCE-MRI detection of pancreatic cancer responses to stroma-directed drug? Proceedings of International Society of Magnetic Resonance in Medicine 2020.
  12. Li Y, Fan Y, Pickup S, Zhou R, Song HK: Murine Abdominal DWI by Under-sampled Radial Acquisition and Deep Learning Reconstruction. CIRP Network Annual Meeting June 2021.
  13. Pickup S, Song HK, Joaquim MRG, Clendenin C, O'Dwyer P, Rosen M, Zhou R: Dynamic Contrast Enhanced MR Imaging of the Mouse Abdomen Using Stack of Stars Sampling. CIRP Network Annual Meeting June 2021.
  14. Choi, Hoon, Lee, Hsiaoju, Pantel, Austin, Hensley, Christopher, Mankoff, David, Zhou, Rong: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutamate transport and glutaminase San Antonio Breast Cancer Symposium 2021 December 2021.
  15. Emma E Furth, Hoon Choi, Miguel R.G. Joaquim, Deidre McMenamin, Stephen Pickup, Hee Kwon Song, Cynthia Clendenin, Yong Fan, Mark Rosen, Thomas Karasic, Jeffrey Duda, James Gee, Peter O'Dwyer, Rong Zhou: Characterization of Pancreatic Cancer Stroma in GEM Models by MRI and IHC. NIH/NCI Oncology Model Forum 2021 2021.
  16. Rong Zhou, Hoon Choi, Hsiaoju Lee, Austin R. Pantel, Christopher Hensley, David A. Mankoff: Dynamic [18F]FSPG PET: impact of glutamate transport and glutaminase inhibition on redox imbalance and cell death in glutamine-dependent triple negative breast cancer SNMMI Annual Meeting 2021; Page: #1240 (Notes: Nominated for poster award).
  17. Tianming Du, Yuemeng Li, Honggang Zhang, Stephen Pickup, Rong Zhou, Hee Kwon Song, Yong Fan: Adaptive convolutional neural networks for accelerating magnetic resonance imaging via k-space data interpolation. Proceedings of International Society of Magnetic Resonance in Medicine Page: 1968, 2021.
  18. Yuemeng Li, Hee Kwon Song, Miguel Joaquim, Stephen Pickup, Rong Zhou, Yong Fan: Deep Learning of ADC Maps from Under-sampled Diffusion-Weighted Radially Sampled MRI. Proceedings of International Society of Magnetic Resonance in Medicine (1221), 2021.
  19. Miguel Romanello Joaquim, Emma E. Furth, Yong Fan, Hee Kwon Song, Stephen Pickup, Jianbo Cao, Hoon Choi, Mamta Gupta, Quy Cao, Russell Shinohara, Deirdre McMenamin, Cynthia Clendenin, Thomas Karasic, Jeffrey Duda, James Gee, Peter O'Dwyer, Mark Rosen, and Rong Zhou. : DWI Metrics Differentiating Intraductal Papillary Mucinous Neoplasms from Pancreatic Cancer: A study in GEM Models. Proceedings of International Society of Magnetic Resonance in Medicine May 2022.
  20. Mark Rosen, Hee Kwon Song, Emma E Furth, Rong Zhou, Peter O'Dwyer, and Thomas Karasic: PENN Quantitative Imaging Resource for Pancreatic Cancer: Clinical trial updates Co-clinical Imaging Resource Program (CIRP) Network Annual Meeting June 2022.
  21. Yuemeng Li, Miguel Romanello Giroud Joaquim, Stephen Pickup, Hee Kwon Song, Rong Zhou and Yong Fan: A deep CNN-transformer model for learning apparent diffusion coefficient maps from under-sampled radial acquisition DWI data. Co-clinical Imaging Resource Program (CIRP) Network Annual Meeting June 2022.

Presentations

  1. CIRP annual meeting talk on Interoperability - 2023
  2. CIRP annual meeting update - 2022
  3. ISMRM 2022 invited talk “Contrast-Enhanced MRI in Cancer: Is It a Biomarker or a Fad?”
  4. Web resource design and contents of the University of Pennsylvania pancreatic cancer imaging resource