Penn Quantitative Imaging Resource for Pancreatic Cancer


UPenn Co-Clinical Imaging Resource Program (U24)



Project Aims


Aim 1

Optimize the preclinical MRI protocols to improve their robustness to respiratory motion-induced corruption, distortion and blur. Assess the repeatability of quantitative imaging markers in GEM model of pancreatic cancer.


Aim 2

Design and perform preclinical studies that match an ongoing clinical trial that evaluate the stroma-directed agent on pancreatic cancer microenvironment. Perform co-clinical imaging studies in human and GEM model.


Aim 3

Build a web resource to demonstrate the effective optimizations of the motion-robust methods, share protocols, tools and SOPs. Enhance the accessibility, clarity and sustainability of the webpage.


big picture diagram

Personnel


Rong Zhou, PhD
Rong Zhou, PhD
Professor of Radiology

Preclinical / Clinical Trials & Quantitative Imaging Methods

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Peter O`Dwyer, MD
Peter O'Dwyer, MD
Director, Developmental Therapeutics Program

Clinical Trials

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Mark A. Rosen, MD, PhD
Mark A. Rosen, MD, PhD
Division Chief, Abdominal Imaging

Clinical Trials

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Stephen Pickup, PhD
Stephen Pickup, PhD
Director, Magnetic Resonance Imaging and Spectroscopy Sub-Core

Quantitative Imaging Methods

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Hee Kwon Song, PhD
Hee Kwon Song, PhD
Associate Professor of Radiologic Science

Quantitative Imaging Methods

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Thomas Karasic, MD
Thomas Karasic, MD
Assistant Professor of Medicine

Clinical Trials

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Emma Furth, MD
Emma Furth, MD
Professor of Pathology and Laboratory Medicine

Clinical Trials

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Cynthia Clendenin, VMD
Cynthia Clendenin, PhD
Scientific Director, Pancreatic Cancer Mouse Hospital

Preclinical trials

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Jinbo Chen, PhD
Jinbo Chen, PhD
Professor Of Biostatistics In Biostatistics And Epidemiology

Preclinical / Clinical Trials

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Yong Phan, PhD
Yong Phan, MD
Assistant Professor of Radiology

Quantitative Imaging Methods

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James C. Gee, PhD
James C. Gee, PhD
Associate Professor of Radiologic Science and Computer and Information Science

Web Resources

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Facilities


Penn Pancreatic Cancer Mouse Hospital
Small Animal Imaging Facility


The Co-Clincal Imaging Resources Program (U24s)

The NCI Co-Clinical Imaging Research Resource Program (CIRP) promotes development of quantitative imaging resources for therapeutic or prevention co-clinical trials that study both patients and human-in-mouse models. The resources will encourage a consensus on optimizing quantitative imaging methods and develop standard operating procedures for co-clinical applications

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NCI CIRP Wiki

The NCI CIRP Wiki will be used as the network workspace for intra-network communications & scientific discussions and serves as the network homepage for publishing news/events and announcing activities externally.

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